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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related ...

18 Feb 2019 ... MEDI3039 killed multiple breast cancer cell lines, but the sensitivity varied among different subtypes. Sensitivity was basal B TNBC >> basal A ...

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Abstract 3494: MEDI3039, a novel highly potent tumor necrosis ...

15 Jul 2019 ... Abstract 3494: MEDI3039, a novel highly potent tumor necrosis factor (TNF)- related apoptosis-inducing ligand (TRAIL) receptor agonist, ...

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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related ...

18 Feb 2019 ... MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression ...

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Abstract P5-03-06: MEDI3039, a novel highly potent tumor necrosis ...

15 Feb 2019 ... Abstract P5-03-06: MEDI3039, a novel highly potent tumor necrosis factor (TNF)- related apoptosis inducing ligand (TRAIL) receptor agonist, ...

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(PDF) MEDI3039, a novel highly potent tumor necrosis factor (TNF ...

24 Dec 2019 ... MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression ...

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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related ...

In this study, we examined MEDI3039, a highly potent multivalent DR5 agonist, in breast cancer cell lines and in vivo models.MethodsAs in vitro model systems, ...

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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related ...

Title: MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic ...

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Abstract P5-03-06: MEDI3039, a novel highly potent tumor necrosis ...

We hypothesized that MEDI3039, developed from this TRAIL super-agonist, is a potential new therapeutic agent to be used in human breast cancer treatment.

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MEDI3039 | BM4 Year 2 Foundations of Medicine | University of ...

MEDI3039 BM4 Year 2 Foundations of Medicine. Module Overview. The BM4 course in years 1 and 2 is a highly contextualised and integrated course in which  ...

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Yoshimi Endo Greer, M.D., Ph.D. | Center for Cancer Research ...

Dr. Yoshimi E. Greer has extensive experience in cell biology, molecular biology, biochemistry and oncology. Her recent research focuses are 1) TRAIL-induced ...

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Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death ...

15 Nov 2019 ... We describe here in vivo imaging measurements of early tumor responses to MEDI3039, and also 5-FU, using NIR fluorophore-labeled C2Am, ...

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Volume 11.06 | Feb 21 - Mammary Cell News

21 Feb 2019 ... The authors examined MEDI3039, a highly potent multivalent death receptor 5 agonist, in breast cancer cell lines and in vivo models.

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Vimentin | BD Biosciences 550513 product information

Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ...

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Anti-Mitochondria antibody [MTC02] (Biotin) (ab79479) | Abcam

Mouse monoclonal Mitochondria antibody [MTC02] conjugated to Biotin. Validated in WB, IHC, ICC/IF and tested in Human. Cited in 3 publication(s).

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IHC-based subcellular quantification provides new insights into ...

14 Aug 2019 ... Greer YE, Tice D, Lipkowitz S . MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) receptor ...

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

18 Jan 2019 ... However, this was not as pronounced as that observed with rTRAIL or the multivalent death receptor five superagonist MEDI3039 (Figure ...

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Predictive & Prognostic Cancer Imaging

21 Jun 2019 ... ... molecular imaging with hyperpolarized [1-13C]pyruvate MRSI and 18FDG-PET of early tumor response to a novel TRAIL agonist (MEDI3039).

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MEDI3039, a novel highly potent tumor ... - CIENCIASMEDICASNEWS

19 Feb 2019 ... MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression ...

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Cancers | Free Full-Text | Novel Apoptosis-Inducing Agents for the ...

31 Jul 2019 ... MEDI3039 is a unique multivalent high potency DR5 agonist [108,109,110]. The multivalent scaffold protein is an engineered protein based on ...

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Dr. Stanley Lipkowitz, MD – Bethesda, MD | Oncology

... J. M.,Pottash, A. E.,Williams, S. C.,Hussain, A.,Lapidus, R. G.,Lipkowitz, S.,Jay, S. M.> ;AAPS J. 2019 Apr 06; MEDI3039, a novel highly potent tumor necrosis ...

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Centre for Drug Development: Strategy and portfolio | Cancer ...

Our ambition is to accelerate the delivery of the next generation of medicines to the patients who need them. As the world's only charity-funded drug ...

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p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime ...

17 Aug 2019 ... Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains ...

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DR5 (B-D37): sc-65314

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic ...

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PDB 4n90 citation summary ‹ Protein Data Bank in Europe (PDBe ...

4n90: Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.

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Scientific Session 18: Oncology - Preclinical Multimodal | WMIS

SS 106: Multi-modality molecular imaging of early tumor response to a novel TRAIL agonist (MEDI3039) in a mouse model of colorectal cancer. Richard Hesketh

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Breast Cancer Res - Publication Information - Medscape

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic ...

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

18 Jan 2019 ... molecule death receptor agonist MEDI3039 and cell viability assessed with XTT assay. (E) The BAP1-wild-type MPP-89 MM line was ...

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(ISMRM 2019) Multi-modality molecular imaging with ...

Multi-modality molecular imaging with hyperpolarized [1-13C]pyruvate MRSI and 18FDG-PET of early tumor response to a novel TRAIL agonist (MEDI3039).

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Publications Authored by Yoshimi Endo Greer | PubFacts

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic ...

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Design, Construction, and In Vitro Analyses of Multivalent Antibodies ...

Kathy Miller, Gloria Meng, Jun Liu, Amy Hurst, Vanessa Hsei, Wai-Lee Wong, Rene Ekert, David Lawrence, Steven Sherwood, Laura DeForge, Jacques ...

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Results and presentations

Full-Year 2019 Investor Roadshows – Amsterdam, Brussels, Edinburgh, Frankfurt , London, Milan, Paris, Stockholm, Zurich, Boston, Chicago, Denver, Los ...

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Part time Bachelor's Degree Programme Optometry

Medi3171. 3. Visual psychophysics vai Psychophysics. B. RedZ1000. 2. Pharmacology of the eye. B. Medi3170. 2. Introduction in the eye diseases. B. Medi3039.

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Full time Bachelor's Degree Programme Optometry

Pharmacology of the eye. B. Medi3170. 2. Introduction in the eye diseases. B. Medi3039. 2. Anomalies of refraction II. B. Fizi3000. 2. Research methods in vision ...

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Direct Comparisons of the Morphology, Migration, Cell Adhesions ...

3 Dec 2010 ... Interactions between cells and the extracellular matrix are at the core of tissue engineering and biology. However, most studies of these ...

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iMig 2019

to both TRAIL and MEDI3039 in 4 BAP1 wild-type. MM lines and in 1 breast carcinoma and 2 clear cell renal cell carcinoma lines. Mutagenesis of BAP1.

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Cancer Research UK Cambridge Institute

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CCRCB ANNUAL REPORT 2019

31 Mar 2019 ... for the phase I trial of MedImmune's MEDI3039 a novel 2nd generation TRAIL receptor agonist. Wilson and McDade are the PI and Scientific ...

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Breast Cancer Res

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis- inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic ...

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